What is the most common inherited bleeding disorder?

The most common inherited bleeding disorder is Von Willebrand disease. This disorder results from a deficiency in von Willebrand factor, which is critical for platelet adhesion during the clotting process. Von Willebrand factor also plays a role in stabilizing factor VIII, a key component in the coagulation cascade.

Although Hemophilia A is indeed a significant and well-known inherited bleeding disorder, it specifically involves a deficiency of factor VIII and is less common than Von Willebrand disease. Hemophilia A primarily affects males and is inherited in an X-linked recessive pattern, while Von Willebrand disease affects both males and females, making it more prevalent in the general population.

Thrombocytopenia refers to a low platelet count and is not classified as an inherited disorder in most cases, although it can have hereditary forms. Disseminated Intravascular Coagulation (DIC) is an acquired condition and not inherited, characterized by systemic activation of coagulation leading to the consumption of platelets and coagulation factors.

These distinctions help clarify why Von Willebrand disease is recognized as the most common inherited bleeding disorder.