ASCP Specialist in Hematology (SH) Practice Exam

Chronic myelogenous leukemia (CML) is characterized by the overproduction of myeloid cells, particularly granulocytes, which includes neutrophils, basophils, and eosinophils. In the context of this question, basophils are particularly notable because their elevated levels are a distinctive feature of CML.

Basophils are a type of white blood cell that plays a role in allergic reactions and fighting parasitic infections. In CML, the percentage of basophils can rise significantly. This increase is a hallmark of the disease and can aid in its diagnosis. In the chronic phase of CML, basophilia is often one of the laboratory findings used to differentiate it from other myeloproliferative neoplasms.

While neutrophils are generally increased in CML, they are not as specific as basophils for this condition when it comes to identifying the disease process. Eosinophils may also be increased in certain circumstances but are not as closely associated with CML as basophils. Thrombocytes (platelets) can be high in CML but are not the primary cell type used to signify the disease in the context of the answer choices.

In summary, elevated bas