What is a defining characteristic of Gaucher cells?

Gaucher cells are a key feature in the diagnosis of Gaucher disease, which is a lysosomal storage disorder. A defining characteristic of these cells is that they are large macrophages filled with lipids due to the accumulation of glucocerebrosides. They typically exhibit a small, eccentric nucleus that is often displaced to the side, giving the cell a distinct appearance. This morphology is important for pathologists when diagnosing Gaucher disease, as it helps differentiate these cells from other types of abnormal cells present in various hematological conditions.

The presence of large, lipid-laden macrophages with eccentric nuclei indicates the overactivity of the macrophages in response to glucocerebroside accumulation. This unique cellular morphology, along with clinical findings and biochemical tests, assists in confirming Gaucher disease. Understanding this characteristic is crucial for both diagnosing the condition and for understanding the underlying pathophysiology of lipid storage disorders.